Circulating Tumor Cells

Automated detection and characterization of rare and circulating tumor cells (CTC)

BioView’s CTC application was designed to automate the imaging and detection of rare and circulating tumor cells, while its unique analysis algorithms provide a set of mathematically based cellular and signal features. These features are vital for assay development and characterization, they improve the sensitivity of detection, reduces analysis time and enable progress validation of research projects.

As the identification and quantification of CTC in peripheral blood sample is an extremely lengthy process, and as CTC research becomes more clinically-oriented, so grows the need for an automated, high-throughput system with specialized algorithms for the detection of the cells of interest. BioView’s CTC application incorporates field-proven algorithms, developed in collaboration with leading cancer research centers worldwide, making it the ideal solution for both clinical and research laboratories looking to enhance their productivity and assay development process.

The application is not available in all markets.

For additional information visit our Regulatory Approvals Page

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Learn more about BioView’s DeNovo CTC system

Features:

Rapid scanning of the entire preparation area
Gallery can be sorted according to statistical data
Unlimited z-stack images and distances
Exported XY coordinates enable cell relocation on any microscope
Automated scan using either x10, x20 ,x40 or x60 objectives
Side by side presentation of all cell related images, captured during the automatic scan
Generated data can be used to create a scatter map, showing distribution of identified cells across the sample
Compatible with any of fluorescent dye (including “Far-Red” fluorophore as CY5 , APC, CY5.5, and CY7)
Automated cell categorization, based on the presence of antibodies or combination of up to eight fluorephores.
Can be adapted to scan standard microscope slides, micro fluidic chips / cartridges and size filtration membranes
Automatic relocation of previously identified cells for:
- Manual observation and interactive image capture (using different magnification, as needed)
- Automated revisit and capture of selected cells of interest, identified during an automatic scan (capture different resolution images, capture new images after second set of markers are applied, etc.)
Statistical, quantitative data is presented as split screen .Statistical, quantitative data can be used to establish a clear clinical scoring criteria
Combined with BioView’s Research Application, supports presentation and export of statistical, quantitative data including:
- Target XY –XY coordinates per target
- Target classification
- Nucleus area
- DAPI mean intensity
- DAPI intensity STD
- Nucleus roundness
- Nucleus average diameter
- Mean signal intensity (for each fluorphore / antibody used)
For research use only